Local Xenotransplantation of Bone Marrow Derived Mast Cells (BMMCs) Improves Functional Recovery of Transected Sciatic Nerve in Cat: A Novel Approach in Cell Therapy
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منابع مشابه
P21: Local Administration of Methylprednisolone Laden Hydrogel Enhances Functional Recovery of Transected Sciatic Nerve in Rat
The repair of peripheral nerve injuries is still one of the most challenging tasks and concerns in neurosurgery. Effect of methylprednisolone-laden hydrogel loaded into a chitosan conduit on the functional recovery of peripheral nerve using a rat sciatic nerve regeneration model was assessed. A 10-mm sciatic nerve defect was bridged using a chitosan conduit (CHIT/CGP-Hydrogel) filled with CGP-h...
متن کاملEffect of Local Transplantation of Bone Marrow Derived Mast Cells (BMMCs) Combined with Chitosan Biofilm on Excisional and Incisional Wound Healing: A Novel Preliminary Animal Study on Lamb
Objective: To determine the effects of bone marrow derived mast cells (BMMCs) on excisional and incisional wound healing in an animal model on lamb.Design- Experimental Study.Animals- Twelve healthy male lambsProcedures: Animals were randomized into four groups of three animals each. In CONTROL animals, the created wounds were left untreated receiving 100 μL PBS. In BMMC group...
متن کاملEvaluation of the Functional Recovery in Sciatic Nerve Injury following the Co-transplantation of Schwann and Bone Marrow Stromal Stem Cells in Rat
Introduction: Transplantation of bone marrow stromal cells (BMSCs) or Schwann cells (SCs) can increase axonal regeneration in peripheral nerve injuries. Based on our previous investigations, the goal of the present work was to examine the individual and synergistic effects of the two different cell types in sciatic nerve injury . We pursued to evaluate the effects of BMSCs and SCs co-transplant...
متن کاملINFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATION
In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...
متن کاملthe effects of schwann and bone marrow stromal stem cells on sciatic nerve injury in rat: a comparison of functional recovery
objective: transplantation of bone marrow stromal cells (bmscs) or schwann cells (scs) can facilitate axonal regeneration in peripheral nerve injuries. the aim of this study was to compare the effects of transplantation of bmscs and scs on functional recovery after injury to the sciatic nerve in the rat. materials and methods:in this experimental research, adult male wistar rats (n=24, 250-300 ...
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ژورنال
عنوان ژورنال: Bulletin of Emergency and Trauma
سال: 2018
ISSN: 2322-3960,2322-2522
DOI: 10.29252/beat-060204